Isoniazid and Pulmonary Fibrosis

To the Editor: The anti-tuberculosis (TB) therapy can cause various drug adverse effects including hepatotoxicity, nephrotoxicity and skin rash.[1,2] There are some case reports about interstitial lung disease (ILD) such as pneumonitis caused by isoniazid (INH), rifampin (RFP), ethambutol (EMB).[3,4] The causative drug was discontinued permanently or re-administrated after desensitization therapy. But the pulmonary fibrosis induced by short anti-TB medication was very rare. We herein report a case of pulmonary fibrosis due probably to INH, which was developed after 3 weeks of anti-TB treatment.